The Knower must study the Secret Molecules designated to each Builder and then give each Builder clue cards that relate to their specific Molecule!
Each Builder must interpret these Clues as they arrange and rearrange their individual Element Tiles, attempting to deduce the structure of their Secret Molecule.
Builders may request new Clues from the Knower as the game progresses with their limited supply of Clue Tokens.
When the Builders think that the molecular structures they have built match their Secret Molecules, they submit their structure to the Knower with a Guess Token.
If the Builders submit their molecular structures and are wrong, they have exhausted precious resources and are that much closer to losing the game.
If the Builders submit their molecular structures and are correct, they receive more Clue Tokens as a reward and may begin building their next Secret Molecule! If each Builder is able to correctly build both of their Secret Molecules, everyone wins!